Reaktion #313981

Reaktionsgleichung

1,4-diaminobenzene

ethyl isocyanate

potassium carbonate

→

4-(ethylaminocarbonylamino)aniline

Ausbeute 62.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture was partitioned in 1N HCl solution (80 mL)
2. 2
   ExtraktionThe aqueous layer was extracted with ethyl acetate (4×80 mL)
3. 3
   SonstigeThe combined organic layers was dried
4. 4
   Sonstigeevaporated
5. 5
   Sonstigerecrystallized from MeOH/CH2Cl2/hexanes

Vorschrift

A mixture of 1,4-diaminobenzene (4 g, 37 mmol), ethyl isocyanate (1 mL, 12.6 mmol) and potassium carbonate (8.72 g, 63 mmol) in THF (20 mL) was stirred at room temperature overnight. The reaction mixture was partitioned in 1N HCl solution (80 mL) and ethyl acetate (80 mL). The aqueous layer was extracted with ethyl acetate (4×80 mL). The combined organic layers was dried, evaporated, recrystallized from MeOH/CH2Cl2/hexanes to give 4-(ethylaminocarbonylamino)aniline (1.4 g, 62%) as a beige solid.

Quelle