Reaktion #313774

ord-80c65d180bcf49589d54026f79d408cb

Reaktionsgleichung

NC12OCCON1C(Nc1ccc3oc(CO)cc3c1)=NC=C2F
N4-(3,4-ethylenedioxy)-5-fluoro-N2-[2-(hydroxymethyl)benzofuran-5-yl]-2,4-pyrimidinediamine
O=C1CCCc2ccc(Nc3nc(Cl)ncc3F)cc21
2-chloro-5-fluoro-N4-(1,2,3,4-tetrahydro-1-oxonaphthalen-7-yl)-4-pyrimidineamine
CC(C)[CH2][Al][CH2]C(C)C
Dibal-H
OC1CCCc2ccc(Nc3nc(Cl)ncc3F)cc21
2-chloro-5-fluoro-N4-(1,2,3,4-tetrahydro-1-hydroxynaphthalen-7-yl)-4-pyrimidineamine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In a manner similar to the preparation of N4-(3,4-ethylenedioxy)-5-fluoro-N2-[2-(hydroxymethyl)benzofuran-5-yl]-2,4-pyrimidinediamine, 2-chloro-5-fluoro-N4-(1,2,3,4-tetrahydro-1-oxonaphthalen-7-yl)-4-pyrimidineamine was reduced with Dibal-H to yield 2-chloro-5-fluoro-N4-(1,2,3,4-tetrahydro-1-hydroxynaphthalen-7-yl)-4-pyrimidineamine.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07557210B2uspto-grants-2009_07