Reaktion #313204

Reaktionsgleichung

potassium methoxide

tris[2-(2-methoxyethoxy)ethyl]amine

8-(1-ethyl-propyl)-2,6-dimethyl-3-(5-fluoro-3-methyl-benzo[b]thiophen-2-yl)-imidazo[1,2-b]pyridazine

→

title compound

8-(1-ethyl-propyl)-2,6-dimethyl-3-(5-methoxy-3-methyl-benzo[b]thiophen-2-yl)-imidazo[1,2-b]pyridazine

Lösungsmittel

dichloromethane

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn an oven dried
2. 2
   Sonstigenitrogen purged
3. 3
   workup.WAITAfter 4 h
4. 4
   SonstigeThe layers are separated
5. 5
   Extraktionthe aqueous is extracted 3×50 mL of dichloromethane
6. 6
   Trocknendried (MgSO4)
7. 7
   Einengenconcentrated under vacuum
8. 8
   SonstigeThe crude mixture is purified by chromatography

Vorschrift

In an oven dried, nitrogen purged, 3 neck, 50 mL round bottom flask, 0.014 g (0.197 mmol) of potassium methoxide and 0.005 mL (0.013 mmol) of tris[2-(2-methoxyethoxy)ethyl]amine are heated at 150° C. and stirred vigorously for 5 minutes. 0.050 g (0.131 mmol) of 8-(1-ethyl-propyl)-2,6-dimethyl-3-(5-fluoro-3-methyl-benzo[b]thiophen-2-yl)-imidazo[1,2-b]pyridazine is added and the reaction is followed by TLC (2:1 Hexanes/Ethyl Acetate) and MS. After 4 h, the reaction mixture is diluted with 20 mL dichloromethane and 20 mL of water. The layers are separated and the aqueous is extracted 3×50 mL of dichloromethane, dried (MgSO4), and concentrated under vacuum. The crude mixture is purified by chromatography using hexanes:ethyl acetate as a solvent system. Combined fractions to obtain 0.015 g of the title compound, 29% yield. MS, ES+=394.2 (M+1); H1NMR (DMSO-d6) δ 7.863-7.842 (d, J=8.368, 1H); 7.327-7.321 (m, 1H); 7.076-7.049 (m, 1H); 6.991 (s, 1H); 3.857 (s, 3H); 3.094 (m, 1H); 2.477 (s, 3H); 2.350 (s, 3H); 2.180 (s, 3H); 1.853-1.760 (m, 4H); 0.793-0.757 (m, 6H) ppm.

Quelle