Reaktion #313150

ord-4c7214504eeb4860acabb139b626737b

Reaktionsgleichung

CON=C1C[C@@H](CC(=O)O)N(C(=O)c2ccc(-c3ccccc3)cc2)C1
[(2S,4EZ)-1-(biphenyl-4-ylcarbonyl)-4-(methoxyimino)pyrrolidin-2-yl]acetic acid
CON=C1C[C@@H](CC(=O)O)N(C(=O)c2ccc(-c3ccccc3)cc2)C1
Intermediate 7
CON=C1C[C@@H](CC(=O)O)N(C(=O)c2ccc(-c3ccccc3)cc2)C1
[(2S,4EZ)-1-(biphenyl-4-ylcarbonyl)-4-(methoxyimino)pyrrolidin-2-yl]acetic acid
C1COCCN1
morpholine
→
CON=C1CC(CC(=O)N2CCOCC2)N(C(=O)c2ccc(-c3ccccc3)cc2)C1
title compound
Ausbeute 98.0%
CON=C1CC(CC(=O)N2CCOCC2)N(C(=O)c2ccc(-c3ccccc3)cc2)C1
biphenyl-4-ylcarbonyl-5-(2-morpholin-4yl-2-oxoethyl) pyrrolidin-3-one O-methyloxime
Ausbeute 98.0%

Edukte

CON=C1C[C@@H](CC(=O)O)N(C(=O)c2ccc(-c3ccccc3)cc2)C1
[(2S,4EZ)-1-(biphenyl-4-ylcarbonyl)-4-(methoxyimino)pyrrolidin-2-yl]acetic acid
CON=C1C[C@@H](CC(=O)O)N(C(=O)c2ccc(-c3ccccc3)cc2)C1
Intermediate 7
CON=C1C[C@@H](CC(=O)O)N(C(=O)c2ccc(-c3ccccc3)cc2)C1
[(2S,4EZ)-1-(biphenyl-4-ylcarbonyl)-4-(methoxyimino)pyrrolidin-2-yl]acetic acid
C1COCCN1
morpholine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe same method as employed in the preparation of Example 7

Vorschrift

The same method as employed in the preparation of Example 7, but starting from [(2S,4EZ)-1-(biphenyl-4-ylcarbonyl)-4-(methoxyimino)pyrrolidin-2-yl]acetic acid (Intermediate 7) and morpholine, gave the title compound. Yield: 98%. HPLC purity: 100%

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07557136B2uspto-grants-2009_07