Reaktion #313040

Reaktionsgleichung

2-amino-5-bromo-3-hydroxymethylpyridine

HBr

→

2-Amino-5-bromo-3-(bromomethyl)pyridine hydrobromide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 12 hrs
2. 2
   EinengenThe reaction was concentrated
3. 3
   Sonstigewas placed under high vacuum overnight

Vorschrift

A solution of 2-amino-5-bromo-3-hydroxymethylpyridine (5.00 g, 24.6 mmole), from Preparation 14(b), in 48% aqueous HBr (50 mL), was heated at reflux for 12 hrs. The reaction was concentrated and toluene was used to azeotrope the residual H2O. The resulting light brown solid was placed under high vacuum overnight and used directly.

Quelle