Reaktion #313039

Reaktionsgleichung

2-amino-3-(hydroxymethyl)pyridine

NBS

→

title compound

Ausbeute 78.0%

2-Amino-5-bromo-3-(hydroxymethyl)pyridine

Ausbeute 78.0%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenwas concentrated
2. 2
   workup.DISSOLUTIONthe residue was dissolved in CHCl3
3. 3
   FiltrationThe resulting suspension was filtered
4. 4
   Einengenthe filtrate was concentrated to a dark oil
5. 5
   SonstigePurification on silica gel (EtOAc)

Vorschrift

To a solution of 2-amino-3-(hydroxymethyl)pyridine (13.0 g, 116.0 mmole) in CH2Cl2 (300 mL) at RT was added NBS (22.71 g, 127.6 mmole). After stirring at RT for 45 min the reaction solution was concentrated and the residue was dissolved in CHCl3. The resulting suspension was filtered and the filtrate was concentrated to a dark oil. Purification on silica gel (EtOAc) afforded the title compound (78%, 18.36 g) as a tan solid: MS (ES) m/e 204 (M+H)+.

Quelle