Reaktion #312913

ord-c7041af22bad428d96c13a14394f49fb

Reaktionsgleichung

CS(=O)(=O)c1ccc(I)c(C(=O)O)c1
2-Iodo-5-methanesulfonyl-benzoic acid
OB(O)c1ccc(F)c(F)c1
3,4-difluoro-benzeneboronic acid
→
CS(=O)(=O)c1ccc(-c2ccc(F)c(F)c2)c(C(=O)O)c1
3′,4′-Difluoro-4-methanesulfonyl-biphenyl-2-carboxylic acid

Edukte

CS(=O)(=O)c1ccc(I)c(C(=O)O)c1
2-Iodo-5-methanesulfonyl-benzoic acid
OB(O)c1ccc(F)c(F)c1
3,4-difluoro-benzeneboronic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared in analogy to Example B25 from 2-Iodo-5-methanesulfonyl-benzoic acid (example B19(b)) and 3,4-difluoro-benzeneboronic acid. Light brown solid. MS (m/e): 311.1 ([M−H], 100%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07557114B2uspto-grants-2009_07