Reaktion #312771

ord-2dd74b8e35284d008f12b9dd43427d71

Reaktionsgleichung

CC(C)(C)OC(=O)N1Cc2ccc(N3CCC(F)(F)CC3)cc2C1
5-(4,4-difluoro-piperidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester
Cl
hydrochloric acid
→
Cl.FC1(F)CCN(c2ccc3c(c2)CNC3)CC1
5-(4,4-Difluoro-piperidin-1-yl)-2,3-Dihydro-1H-isoindole hydrochloride

Edukte

CC(C)(C)OC(=O)N1Cc2ccc(N3CCC(F)(F)CC3)cc2C1
5-(4,4-difluoro-piperidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester
Cl
hydrochloric acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared in analogy to Example A3(e) from 5-(4,4-difluoro-piperidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and hydrochloric acid. Light yellow solid. MS (m/e): 239.3 ([M+H]+, 100%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07557114B2uspto-grants-2009_07