Reaktion #312633

Reaktionsgleichung

1-Hydroxy-cyclopropanecarboxylic acid methyl ester

tetrahydrofuran

Sodium hydride

→

title product

1-Methoxy-cyclopropanecarboxylic acid methyl ester

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture was quenched with ammonium chloride
2. 2
   Extraktionextracted with ethylacetate

Vorschrift

1-Hydroxy-cyclopropanecarboxylic acid methyl ester (1.1 6 gm, 10 mmol) was dissolved in 10 ml of tetrahydrofuran and cooled under a nitrogen atmosphere to 0° C. Sodium hydride (0.52 gm, 60% oil dispersion) was added portionwise followed by lodomethane (1 ml) and stirred for 18 hrs. The reaction mixture was quenched with ammonium chloride and extracted with ethylacetate to obtain 2 gm of title product. (MH+=130)

Quelle