Reaktion #312451

Reaktionsgleichung

3-dimethylamino-3'-(trifluoromethyl)acrylophenone

acetic

3-aminopyrazole-4,5-dicarbonitrile

→

3-Cyano-7-(α,α,α-trifluoro-m-tolyl)pyrazolo-[1,5-a]pyrimidine-2-carbonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 4.86 g
2. 2
   Sonstigethe solvent removed under reduced pressure
3. 3
   SonstigeThe residue is reacted with trifluoroacetic anhydride
4. 4
   Sonstigeto give the product of the example

Vorschrift

A mixture of 4.86 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 50 ml. of glacial acetic and 2.66 g. of 3-aminopyrazole-4,5-dicarbonitrile is refluxed for 10 hours and the solvent removed under reduced pressure. The residue is reacted with trifluoroacetic anhydride to give the product of the example.

Quelle