Reaktion #312446

Reaktionsgleichung

7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

diborane

→

3-Methyl-7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine

Lösungsmittel

tetrahydrofuran

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONthe mixture is poured onto ice
2. 2
   Extraktionthe product extracted into dichloromethane
3. 3
   WaschenThe dichloromethane layer is washed with water
4. 4
   Trocknendried (MgSO4)
5. 5
   Sonstigethe solvent removed
6. 6
   Sonstigeto give the product of the example

Vorschrift

A solution of 0.01 mole of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid in tetrahydrofuran is added dropwise to a chilled (0° C.) solution of 0.02 mole of diborane in tetrahydrofuran. After standing overnight the mixture is poured onto ice and the product extracted into dichloromethane. The dichloromethane layer is washed with water, dried (MgSO4) and the solvent removed to give the product of the example.

Quelle