Reaktion #312378

ord-3c2e6d1e453a4b2e92f969b21ab48ab7

Reaktionsgleichung

CN1C[C@H](CNN)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21
6-methyl-8β-hydrazinomethyl-ergoline
CN(C)C(=O)Cl
dimethylcarbamoyl chloride
→
CN(C)C(=O)NNC[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1
6-methyl-8β-([N'-dimethylcarbamoyl-hydrazino]-methyl)-ergoline
Ausbeute 69.0%

Edukte

CN1C[C@H](CNN)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21
6-methyl-8β-hydrazinomethyl-ergoline
CN(C)C(=O)Cl
dimethylcarbamoyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The process is carried out as in Example 4 with the difference that 0.6 g (0.00213 moles) of 6-methyl-8β-hydrazinomethyl-ergoline and 0.25 g (0.00234 moles) of dimethylcarbamoyl chloride are used as the starting substances. 0.5 g (69%) of 6-methyl-8β-([N'-dimethylcarbamoyl-hydrazino]-methyl)-ergoline are obtained; m.p.: 205°-206° C., [α]D20 =-36.2° (c=1, in 96% ethanol).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04235912uspto-grants-1980_11