Reaktion #312129

Reaktionsgleichung

3-chloro-4-fluoroaniline

2-isocyanato-propionic acid ethyl ester

→

3-(3-chloro-4-fluorophenyl)-5-methyl-hydantoin

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas maintained at 130°-140° C. for 91/2 hours
2. 2
   SonstigeThe resulting product was crystallized from chloroform/methanol

Vorschrift

A mixture of 2.91 g (20 mmol) of 3-chloro-4-fluoroaniline and 3.01 g (21 mmol) of 2-isocyanato-propionic acid ethyl ester was maintained at 130°-140° C. for 91/2 hours. The resulting product was crystallized from chloroform/methanol to yield 3-(3-chloro-4-fluorophenyl)-5-methyl-hydantoin, m.p. 174°-175.5° C.

Quelle