Reaktion #311668

Reaktionsgleichung

ethyl nitrite

4-Methyl-pyrimidine

HCl

→

title compound

Ausbeute 71.0%

4-Formyl-pyrimidine-oxime

Ausbeute 71.0%

Lösungsmittel

ethyl alcohol

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeat 5°
2. 2
   SonstigeThe thus formed 4-formyl-pyrimidine-oxime hydrochloride was separated by filtration
3. 3
   workup.DISSOLUTIONdissolved in water
4. 4
   workup.ADDITIONby adding Na2CO3

Vorschrift

4-Methyl-pyrimidine (0.1 M) was added to 100 ml of ethanol containing 3.5 g (0.1 M) of HCl. While keeping the reaction mixture at 5° there was added over 60 minutes a solution of 9 g (0.12 M) of ethyl nitrite in 60 ml of ethyl alcohol, whereupon the whole was kept under stirring for 1 hour at room temperature. The thus formed 4-formyl-pyrimidine-oxime hydrochloride was separated by filtration, dissolved in water and the aqueous solution neutralized by adding Na2CO3. The title compound was finally obtained by filtration and drying. M.p. 154°-155°. Yield 71%.

Quelle