Reaktion #311512

Reaktionsgleichung

3,4-Dimethoxyphenylacetic acid

thionyl chloride

→

3,4-dimethoxyphenylacetyl chloride

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 2 hr
2. 2
   SonstigeThe solvent and SOCl2 were removed on a rotary evaporator
3. 3
   workup.ADDITIONTwo additional quantities of dry benzene were added to the residue
4. 4
   Sonstigefollowed by rotary evaporation which

Vorschrift

3,4-Dimethoxyphenylacetic acid (6.47 g, 0.033 mole) was dissolved in 50 ml of dry benzene and refluxed for 2 hr. with excess thionyl chloride (25 ml). The solvent and SOCl2 were removed on a rotary evaporator. Two additional quantities of dry benzene were added to the residue, followed by rotary evaporation which yielded 3,4-dimethoxyphenylacetyl chloride.

Quelle