Reaktion #310364

Reaktionsgleichung

3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione

nitric acid

→

3,4-dihydro-4-methyl-7-nitro-2H-1,4-benzodiazepine-2,5(1H)-dione

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitated material is filtered off under suction
2. 2
   Waschenwashed with water
3. 3
   Sonstigedried at 70° in vacuo

Vorschrift

300 ml of 89 percent nitric acid are treated portionwise at room temperature over a period of 35 minutes with 94.5 g (496.8 mmol) of 3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione. The mixture is stirred at room temperature for 18 hours and poured into 3.5 l of ice-water. The precipitated material is filtered off under suction, washed with water and dried at 70° in vacuo. There is obtained 3,4-dihydro-4-methyl-7-nitro-2H-1,4-benzodiazepine-2,5(1H)-dione of melting point 252°-253°.

Quelle