Reaktion #310319

Reaktionsgleichung

trichloroacetamidine

methyl acetoacetate

potassium carbonate

→

4-Hydroxy-6-Methyl-2-Trichloromethylpyrimidine

Ausbeute 46.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA trace of solid was removed by filtration
2. 2
   SonstigeThe product precipitated out
3. 3
   Sonstigeto give 28.9 g (46% yield; mp 173°-174° C.)

Vorschrift

A mixture of 44.4 g (0.28 mole) trichloroacetamidine, 32.0 g (0.28 mole) methyl acetoacetate, 37.5 g (0.28 mole) potassium carbonate, and 450 ml water was stirred for 3 days. A trace of solid was removed by filtration and the filtrate was made acidic with hydrochloric acid. The product precipitated out to give 28.9 g (46% yield; mp 173°-174° C.). The structure was confirmed via mp*, infrared, and elemental analysis.

Quelle