Reaktion #3103

Reaktionsgleichung

1,8-diaza-bicyclo[5.4.0]undec-7-ene

ethyl 3-(4-methoxyphenyl)-3-oxopropionate

3,4-methylenedioxy-1-(2-nitroethenyl)-benzene

→

Ethyl 2-(4-methoxybenzoyl)-3-(3,4-methylenedioxy-phenyl)-4-nitro-butanoate

Lösungsmittel

ethyl acetate

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered through dicalite
2. 2
   Filtrationthe resulting filtered solution
3. 3
   Sonstigewas used in the next step without any further purification

Vorschrift

Into a 45-L stirred reactor at ambient temperature were charged 5.819 kg (30.1 moles) 3,4-methylenedioxy-1-(2-nitroethenyl)-benzene and 24 L ethyl acetate. A solution of 5.355 kg (24.1 moles) ethyl 3-(4-methoxyphenyl)-3-oxopropionate in 16 L ethyl acetate was added. 280 g (275 ml, 1.84 moles) of 1,8-diaza-bicyclo[5.4.0]undec-7-ene in four equal portions was added over a 2.5 hour period. The reaction mixture was filtered through dicalite and the resulting filtered solution was used in the next step without any further purification.

Quelle