Reaktion #3097

Reaktionsgleichung

2,3-dihydrobenzofuran

α,α-dichloromethyl methyl ether

→

title compound

Ausbeute 60.3%

2,3-Dihydrobenzofuran-5-carboxaldehyde

Ausbeute 60.3%

Lösungsmittel

ether

CH2Cl2

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirred a further 30 minutes
2. 2
   Sonstigethe phases separated
3. 3
   EinengenThe organic phase was concentrated in vacuo
4. 4
   workup.DISTILLATIONthe residue purified by vacuum distillation

Vorschrift

To a stirred solution of α,α-dichloromethyl methyl ether (2.15 g, 19 mmol, 1.35 eq) in methylene chloride (30 mL) at -40° C. was added successively stannic chloride (1.65 g, 17 mmol, 1.2 eq) and 15 minutes later, a solution of 2,3-dihydrobenzofuran (1.68 g, 14 mmol) in CH2Cl2 (5 mL) maintaining the temperature at or below -35° C. The mixture was warmed to 0° C., stirred 1 hour, then poured into ice-water, and stirred a further 30 minutes. The mixture was diluted with ether, and the phases separated. The organic phase was concentrated in vacuo, and the residue purified by vacuum distillation to yield the title compound (1.25 g, 60%) as a colorless liquid. b.p. 119°-121° C. at 0.3 mm Hg.

Quelle