Reaktion #309605

Reaktionsgleichung

diethyl 1,4-bis[(phenylmethyl)oxy]-2,3-naphthalenedicarboxylate

sodium hydroxide

→

title compound

Ausbeute 89.7%

1,4-Bis[(phenylmethyl)oxy]-2,3-naphthalenedicarboxylic acid

Ausbeute 89.7%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 2 hours
2. 2
   TemperaturThe reaction mixture was cooled
3. 3
   Sonstigeevaporated
4. 4
   Filtrationthe resulting cream solid was collected by filtration
5. 5
   Waschenwashed with water
6. 6
   SonstigeThis was dried under vacuum

Vorschrift

A mixture of diethyl 1,4-bis[(phenylmethyl)oxy]-2,3-naphthalenedicarboxylate (4.78 g, 9.88 mmol), ethanol (75 ml), and 2N aqueous sodium hydroxide solution (75 ml) was refluxed for 2 hours. The reaction mixture was cooled and evaporated. This was acidified with HCl (2N) and the resulting cream solid was collected by filtration and washed with water. This was dried under vacuum to give the title compound (3.79 g, 8.86 mmol). LC/MS: Rt=3.15, [MH]− 427.

Quelle