Reaktion #309433

Reaktionsgleichung

tert-butyl 4-hydrazinopiperidine-1-carboxylate

phenyl malonaldehyde

→

tert-butyl 4-(4-phenyl-1H-pyrazol-1-yl)piperidine-1-carboxylate

Ausbeute 23.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction liquid
2. 2
   Einengenwas concentrated under reduced pressure
3. 3
   Sonstigethe residue was purified by silica gel column chromatography (hexane/chloroform-50/50 to 0/100)

Vorschrift

To a solution of tert-butyl 4-hydrazinopiperidine-1-carboxylate (646 mg) and ethanol (15 mL) was added phenyl malonaldehyde (444 mg), followed by stirring at 75° C. for about 1.5 days. The reaction liquid was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane/chloroform-50/50 to 0/100) to obtain tert-butyl 4-(4-phenyl-1H-pyrazol-1-yl)piperidine-1-carboxylate (226 mg).

Quelle