Reaktion #309183

Reaktionsgleichung

tert-butyl [2-(4-bromophenyl)-5,8-dioxaspiro[3.4]oct-2-yl]carbamate

tert-Butyl [2-(4-bromophenyl)-5,8-dioxaspiro[3.4]oct-2-yl]carbamate

NaHCO3

→

2-(4-bromophenyl)-5,8-dioxaspiro[3.4]octan-2-amine

2(4-bromophenyl)-5,8-dioxaspiro[3.4]octan-2-amine

Lösungsmittel

TFA

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with CHCl3
2. 2
   Trocknendried (Na2SO4)
3. 3
   Filtrationfiltered
4. 4
   Einengenconcentrated under reduced pressure

Vorschrift

A mixture of tert-butyl [2-(4-bromophenyl)-5,8-dioxaspiro[3.4]oct-2-yl]carbamate (1-5) (3.7 g, 9.63 mmol) in TFA (20 mL) was stirred at room temperature for 1 hour. The mixture was poured into a sat. NaHCO3 solution, extracted with CHCl3, dried (Na2SO4), filtered, and concentrated under reduced pressure to give 2-(4-bromophenyl)-5,8-dioxaspiro[3.4]octan-2-amine (7-1).

Quelle