Reaktion #309129

Reaktionsgleichung

sodium hydrogen carbonate

[3-bromo-5-[(4-ethylphenyl)methyl]-naphthalen-2-yl]-methanol

2-methoxypropene

→

titled compound

Ausbeute 100.0%

7-bromo-1-[(4-ethylphenyl)methyl]-6-[(1-methoxy-1-methylethoxy)methyl]-naphthalene

Ausbeute 100.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooling
2. 2
   ExtraktionThe resultant mixture was extracted with ethyl acetate
3. 3
   TrocknenThe organic layer was dried over anhydrous magnesium sulfate
4. 4
   Einengenconcentrated under reduced pressure

Vorschrift

Under a nitrogen stream, to a solution of [3-bromo-5-[(4-ethylphenyl)methyl]-naphthalen-2-yl]-methanol (326.2 mg, 0.92 mmol) and pyridinium p-toluenesulfonate (4.6 mg, 0.02 mmol) in THF (3.0 mL) was added 2-methoxypropene (0.44 mL, 4.6 mmol) under ice-cooling, and the resultant mixture was stirred at the same temperature for 1.5 hours. Saturated aqueous sodium hydrogen carbonate was added thereto. The resultant mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure, to thereby obtain the titled compound (393.2 mg, 100%).

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