Reaktion #309126

Reaktionsgleichung

potassium carbonate

(2-bromo-4-hydroxymethyl-naphthalen-1-yl)-methanol

2-methoxypropene

THF

→

titled compound

Ausbeute 100.0%

2-bromo-1,4-bis-[(1-methoxy-1-methylethoxy)methyl]-naphthalene

Ausbeute 100.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe resultant mixture was twice extracted with ethyl acetate
2. 2
   WaschenThe organic layer was washed with saturated brine
3. 3
   Trocknendried (anhydrous magnesium sulfate)
4. 4
   SonstigeSolvent was then removed by distillation under reduced pressure

Vorschrift

Under a nitrogen stream, to a solution of (2-bromo-4-hydroxymethyl-naphthalen-1-yl)-methanol (124 mg, 0.464 mmol) and pyridinium p-toluenesulfonate (3 mg, 0.012 mmol) in THF (5 mL) was added 2-methoxypropene (0.134 mL, 1.399 mmol) under ice cooling, and the resultant mixture was stirred at the same temperature for 1 hour. Saturated aqueous potassium carbonate was added thereto, and the resultant mixture was twice extracted with ethyl acetate. The organic layer was washed with saturated brine and dried (anhydrous magnesium sulfate). Solvent was then removed by distillation under reduced pressure, to thereby obtain the titled compound (191 mg, 100%).

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