Reaktion #309101

Reaktionsgleichung

sodium hydrogen carbonate

2-methoxypropene

(2-Bromo-5-fluoro-4-hydroxymethylphenyl)-methanol

tetrahydrofuran

→

titled compound

Ausbeute 97.0%

1-bromo-4-fluoro-2,5-bis-(1-methoxy-1-methyl-ethoxymethyl)-benzene

Ausbeute 97.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe resultant mixture was extracted with ethyl acetate
2. 2
   TrocknenThe organic layer was dried over anhydrous sodium sulfate
3. 3
   Einengenconcentrated under reduced pressure

Vorschrift

(2-Bromo-5-fluoro-4-hydroxymethylphenyl)-methanol (71.3 mg, 0.303 mmol) was dissolved in tetrahydrofuran (1 mL), and 2-methoxypropene (214.7 mg, 2.97 mmol) was added thereto. The resultant mixture was cooled to 0° C., and then p-toluenesulfonic acid (1.0 mg. 0.0029 mmol) was added thereto. This mixture was stirred for 40 minutes, and then saturated aqueous sodium hydrogen carbonate was added. The resultant mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and then concentrated under reduced pressure, to thereby obtain the titled compound (111.7 mg, 97%).

Quelle