Reaktion #309036

Reaktionsgleichung

water

4,5-dichloropyridazin-6-one

N,N-diisopropylethylamine

bromomethyl methyl ether

→

4,5-dichloro-2-methoxymethyl-2H-pyridazin-3-one

Ausbeute 74.8%

Lösungsmittel

methylenechloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeat room temperature
2. 2
   Einengenwas then concentrated
3. 3
   SonstigePurification by column chromatography (1% MeOH in CH2Cl2)

Vorschrift

To a stirred solution of 4,5-dichloropyridazin-6-one (5.00 g, 30.3 mmol) and N,N-diisopropylethylamine (7.92 mL, 45.5 mmol) in methylenechloride (50 mL) was added slowly, bromomethyl methyl ether (4.79 mL, 60.6 mmol) at room temperature (water-bath). The reaction was stirred for 22 h and was then concentrated. Purification by column chromatography (1% MeOH in CH2Cl2) gave 4.74 g (74.8%) of 4,5-dichloro-2-methoxymethyl-2H-pyridazin-3-one.

Quelle