Reaktion #308995

Reaktionsgleichung

4-hydroxyphenylacetone

potassium carbonate

1-bromo-3-chloro-propane

→

1-[4-(3-chloro-propoxy)phenyl]propan-2-one

Ausbeute 93.0%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added dropwise
2. 2
   FiltrationThe mixture was then filtered through celite
3. 3
   Waschenwashed with acetone
4. 4
   Einengenconcentrated

Vorschrift

A solution of 4-hydroxyphenylacetone (4.5 g, 30 mmol) and potassium carbonate (4.14 g, 3.0 eq.) in 50 mL of acetone was stirred under N2 as 1-bromo-3-chloro-propane was added dropwise. The reaction was heated to 80° C. overnight. The mixture was then filtered through celite, washed with acetone and concentrated to afford 1-[4-(3-chloro-propoxy)phenyl]propan-2-one (6.3 g, 93% yield): MS m/z 227 (M+H).

Quelle