Reaktion #308714

Reaktionsgleichung

7-benzyloxyquinolin-4-ol

Nitric acid

→

7-benzyloxy-3-nitroquinolin-4-ol

Lösungsmittel

propionic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwhile maintaining the reaction temperature between 121° C. and 125° C
2. 2
   workup.ADDITIONAfter the addition
3. 3
   Temperaturto cool to ambient temperature
4. 4
   SonstigeThe resulting solid was isolated by filtration
5. 5
   Waschenwashed with water
6. 6
   Sonstigedried in an oven for 1.5 days

Vorschrift

A mixture of 7-benzyloxyquinolin-4-ol (71.47 g, 0.2844 mol) and propionic acid (700 mL) was heated to 125° C. with vigorous stirring. Nitric acid (23.11 mL of 16 M) was slowly added over a period of 30 minutes while maintaining the reaction temperature between 121° C. and 125° C. After the addition, the reaction was stirred at 125° C. for 1 hour then allowed to cool to ambient temperature. The resulting solid was isolated by filtration, washed with water, and dried in an oven for 1.5 days to provide 69.13 g of 7-benzyloxy-3-nitroquinolin-4-ol as a grayish powder.

Quelle