Reaktion #3084

ord-5df4ba9dfa614b57afe5f1e9bd2ce8ad

Reaktionsgleichung

CC(=O)Nc1ccc(OC(C)(C)C(=O)O)cc1
2-(4-acetaminophenoxy)-2-methyl propionic acid
CC(=O)O
acetic acid
→
CC(C)(Oc1ccc(N)cc1)C(=O)O
2-(4-aminophenoxy)-2-methyl propionic acid
Ausbeute 62.0%

Edukte

CC(=O)Nc1ccc(OC(C)(C)C(=O)O)cc1
2-(4-acetaminophenoxy)-2-methyl propionic acid
CC(=O)O
acetic acid

Reagenzien

Keine

Lösungsmittel

[K+].[OH-]
KOH

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    TemperaturThe solution is then cooled

Vorschrift

1.18 g (0.005 mol) of the 2-(4-acetaminophenoxy)-2-methyl propionic acid is boiled in 10% KOH (60 ml) for 1/2 hour. The solution is then cooled and acidified with acetic acid to yield 0.6 g (62% yield) of 2-(4-aminophenoxy)-2-methyl propionic acid as a yellowish white powder, mp 214°-16° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05731454uspto-grants-1998_03