Reaktion #307666

Reaktionsgleichung

potassium carbonate

1H-pyrazole-4-carboxaldehyde

DCM

cyclopropylbromide

→

1-Cyclopropyl-1H-pyrazole-4-carbaldehyde

Lösungsmittel

N,N-dimethylformamide

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturCool to ambient temperature
2. 2
   ExtraktionSeparate layers and extract water layer 3 times with DCM
3. 3
   WaschenWash
4. 4
   Trocknendry (magnesium sulfate)
5. 5
   Filtrationfilter
6. 6
   Einengenconcentrated
7. 7
   Sonstigeto give the free base of the title
8. 8
   Sonstigepreparation

Vorschrift

Dissolve 1H-pyrazole-4-carboxaldehyde in N,N-dimethylformamide (1.9 mL). Add potassium carbonate (0.539 g, 3.90 mmol) and cyclopropylbromide (0.346 g, 2.86 mmol). Heat in a pressure tube to 130° C. for 18 hr. Cool to ambient temperature and add DCM and water. Separate layers and extract water layer 3 times with DCM. Wash combined DCM layers with brine, dry (magnesium sulfate), filter, and concentrated to give the free base of the title preparation. GC-MS: m/z=136 [M+].

Quelle