Reaktion #307520

Reaktionsgleichung

isoniazid

streptomycin

ethambutol

Pyrazinamide

rifampicin

→

isoniazid

streptomycin

ethambutol

SQ109

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONin distilled
2. 2
   Filtrationdeionized water at 10 mg/mL, sterilized by filtration
3. 3
   SonstigeStock solutions of rifampicin, at 1 or 10 mg/mL, were prepared in methanol
4. 4
   Sonstigestored at −80° C
5. 5
   Sonstige, and a stock solution was prepared
6. 6
   Sonstigestored at 80° C.

Vorschrift

Antimicrobial drugs isoniazid, rifampicin, streptomycin, and ethambutol were purchased from Sigma-Aldrich. St. Louis, Mo. Stock solutions of isoniazid, streptomycin, and ethambutol were prepared in distilled and deionized water at 10 mg/mL, sterilized by filtration, and stored frozen at −80° C. Stock solutions of rifampicin, at 1 or 10 mg/mL, were prepared in methanol and stored at −80° C. Pyrazinamide was purchased as the drug reconstituting kit from Becton Dickinson, Cockeysville, Md., and a stock solution was prepared following instructions by the manufacturer. Stock solutions of SQ109 were prepared in methanol at 1 mg/mL and stored at 80° C.

Quelle