Reaktion #307237

Reaktionsgleichung

water

triethylamine

thiomorpholine 1,1-dioxide hydrochloride

4-nitrophenyl chloroformate

→

4-Nitrophenyl thiomorpholine-4-carboxylate 1,1-dioxide

Lösungsmittel

ethyl acetate

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwhile cooling with an ice bath
2. 2
   Filtrationfiltered
3. 3
   SonstigeThe residue was dried under high vacuum

Vorschrift

17.0 g (99.2 mmol) of thiomorpholine 1,1-dioxide hydrochloride were initially charged in 100 ml of dichloromethane and, while cooling with an ice bath, admixed with 20.7 ml (15.1 g, 148.8 mmol) of triethylamine. 10.0 g (49.6 mmol) of 4-nitrophenyl chloroformate were added in portions. The reaction mixture was stirred at RT for 30 minutes, admixed with water and ethyl acetate and then filtered. The residue was dried under high vacuum. Yield: 12.4 g (83% of theory)

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