Reaktion #307102

Reaktionsgleichung

Oxalyl chloride

Intermediate 8

3-methoxy-4-(4-methyl-3-thienyl)benzoic acid

4-(aminosulfonyl)-N′-hydroxybenzenecarboximidamide

DIEA

4-cyanobenzene-1-sulfonamide

→

title compound

4-{5-[3-methoxy-4-(4-methyl-3-thienyl)phenyl]-1,2,4-oxadiazol-3-yl}benzenesulfonamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewere reacted
2. 2
   SonstigePurification
3. 3
   Sonstigeby recrystallisation from DCM/n-pentane

Vorschrift

Oxalyl chloride (123 mL; 1.45 mmol), Intermediate 8 (120 mg; 0.48 mmol), 4-(aminosulfonyl)-N′-hydroxybenzenecarboximidamide, prepared as described in WO 2006/013104 A1 from 4-cyanobenzene-1-sulfonamide (ABCR; CD10716), (104 mg; 05 mmol, 1 eq.) and DIEA (250 mL; 1.45 mmol) were reacted according to the procedure described for Example 38. Purification by recrystallisation from DCM/n-pentane afforded the title compound as a white solid. LC/MS (Method A): 426.3 (M−H)−. HPLC (Method A) Rt 4.93 min (purity 89.2%).

Quelle