Reaktion #306962

Reaktionsgleichung

Intermediate 5

2-methyl-2′-(trifluoromethyl)biphenyl-4-carboxylic acid

methyl 2-methoxy-2′-methylbiphenyl-4-carboxylate

→

title compound

Ausbeute 83.0%

2-methoxy-2′-methylbiphenyl-4-carboxylic acid

Ausbeute 83.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe title compound was prepared following procedure

Vorschrift

The title compound was prepared following procedure described for Intermediate 5, step 2, but starting from methyl 2-methoxy-2′-methylbiphenyl-4-carboxylate (2.50 g; 9.75 mmol; 1 eq.), affording the title compound as a beige solid (1.95 g, 83%). 1H NMR: (DMSO-d6, 300 MHz) δ 13.06 (s, 1H), 7.66-7.61 (m, 2H), 7.31-7.23 (m, 4H), 7.15-7.13 (d, J=7.28 Hz, 1H), 3.80 (s, 3H), 2.07 (s, 3H). LC/MS (Method A): 240.9 (M−H)−. HPLC (Method A) Rt 4.05 min (Purity: 97.3%).

Quelle