Reaktion #306961

Reaktionsgleichung

Intermediate 5

2-methyl-2′-(trifluoromethyl)biphenyl-4-carboxylic acid

methyl 3-methoxy-4-(4-methyl-3-thienyl)benzoate

→

title compound

Ausbeute 83.1%

3-methoxy-4-(4-methyl-3-thienyl)benzoic acid

Ausbeute 83.1%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe title compound was prepared following procedure

Vorschrift

The title compound was prepared following procedure described for Intermediate 5, step 2, but starting from methyl 3-methoxy-4-(4-methyl-3-thienyl)benzoate (2.30 g; 8.77 mmol; 1 eq.), affording the title compound as a brown solid (1.81 g, 83%). 1H NMR: (DMSO-d6, 300 MHz) δ 13.05 (s, 1H), 7.62-7.59 (m, 2H), 7.40-7.39 (d, J=3.23 Hz, 1H), 7.32-7.29 (d, J=7.48 Hz, 1H), 7.25-7.23 (m, 1H), 3.82 (s, 3H), 2.99 (s, 3H). LC/MS (Method A): 248.8 (M+H)+; 246.9 (M−H)−. HPLC (Method A) Rt 3.99 min (Purity: 97.4%).

Quelle