Reaktion #306960

Reaktionsgleichung

Intermediate 5

2-methyl-2′-(trifluoromethyl)biphenyl-4-carboxylic acid

methyl 4-bromo-3-methoxybenzoate

4-methyl-3-thiopheneboronic acid

→

title compound

methyl 3-methoxy-4-(4-methyl-3-thienyl)benzoate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas isolated as a brown oil
2. 2
   SonstigeIt was used in the next step without further purification

Vorschrift

The title compound was prepared following procedure described for Intermediate 5, step 1, but starting from methyl 4-bromo-3-methoxybenzoate (Combi-Blocks, 2.50 g; 10.20 mmol; 1 eq.) and 4-methyl-3-thiopheneboronic acid (1.59 g; 11.22 mmol; 1.10 eq.), and was isolated as a brown oil. It was used in the next step without further purification. LC/MS (Method A): 262.8 (M+H)+. HPLC (Method A) Rt 4.79 min.

Quelle