Reaktion #3065

Reaktionsgleichung

caprolactone

LDA

benzylbromide

→

2-benzylcaprolactone

Lösungsmittel

THF

THF

DMPU

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGafter stirring for 1 h at -15° C.

Vorschrift

A solution of 1 mmol of caprolactone in 0.5 mL THF was added to a solution of LDA in 0.5 mL THF at -78° C. and this stirred for 2 h. Then a solution of 1.1 mmol of a benzylbromide in 0.14 mL DMPU was added to the above mixture and after stirring for 1 h at -15° C., the 2-benzylcaprolactone was isolated by extraction and chromatography.

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