Reaktion #306243

Reaktionsgleichung

1-(6-chloropyridazin-3-yl)hydrazine

1-hydroxy-7-aza-benzotriazole

EDC

2-(7-methoxyquinolin-4-yloxy)acetic acid

diisopropylethylamine

→

N′-(6-chloropyridazin-3-yl)-2-(7-methoxyquinolin-4-yloxy)acetohydrazide

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenConcentrated
2. 2
   EinengenConcentrated
3. 3
   Temperaturwith cooling
4. 4
   Sonstigewas isolated by filtration
5. 5
   SonstigeUsed without further purification

Vorschrift

A mixture of 1-(6-chloropyridazin-3-yl)hydrazine (0.372 g, 2.57 mmol), 1-hydroxy-7-aza-benzotriazole (0.350 g, 2.57 mmol), EDC (0.641 g, 3.34 mmol), 2-(7-methoxyquinolin-4-yloxy)acetic acid (0.600 g, 2.57 mmol) and diisopropylethylamine (1.34 ml, 7.72 mmol) in DMF (20 mL) was allowed to stir at 50° C. for 2 h. Concentrated. Reconstitued in MeCN (30 mL). Concentrated with cooling. Product crashed out of solution and was isolated by filtration. Used without further purification. (ESI, pos. ion) m/z: 234.1 (M+H). Step 3.

Quelle