Reaktion #306164

Reaktionsgleichung

1-benzothien-2-yl(5-bromo-2-fluorophenyl)methanol

thionyl chloride

→

2-[(5-bromo-2-fluorophenyl)(chloro)methyl]-1-benzothiophene

Ausbeute 100.0%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeat a temperature of 5° C.
2. 2
   workup.DISTILLATIONThe reaction mixture was subjected to distillation under reduced pressure
3. 3
   workup.DISTILLATIONto distill off the solvent
4. 4
   Sonstigedrying

Vorschrift

Into an acetonitrile (10 ml) solution of 1-benzothien-2-yl(5-bromo-2-fluorophenyl)methanol (1.0 g) was dropwise added thionyl chloride (706 mg) at a temperature of 5° C. or lower, followed by stirring at 5.0 to 25.0° C. for 3.5 hours. The reaction mixture was subjected to distillation under reduced pressure to distill off the solvent and the residue was subjected to vacuum drying to obtain 2-[(5-bromo-2-fluorophenyl)(chloro)methyl]-1-benzothiophene [1.05 g, yield: 100%, purity: 99% (HPLC)].

Quelle