Reaktion #3061

Reaktionsgleichung

CO2

2-isopropylthiophenol

TMEDA

n-BuLi

→

2-mercapto-3-isopropylbenzoic acid

Lösungsmittel

cyclohexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirred for 16 h
2. 2
   Extraktionwhen extraction and chromatography

Vorschrift

To a solution of 1.0 mmol 2-isopropylthiophenol and 2.2 mmol TMEDA in 2 mL cyclohexane was added 2.2 mmol n-BuLi. Then after stirring 24 h it was added to solid CO2 and stirred for 16 h when extraction and chromatography provided 2-mercapto-3-isopropylbenzoic acid. The methyl ester of this was treated as in example 3 to provide the title compound.

Quelle