Reaktion #3058

Reaktionsgleichung

cycloheptylamine

diisopropylethylamine

bromoacetyl bromide

→

solid

Ausbeute 89.7%

Bromo-N-cycloheptyl acetamide

Ausbeute 89.7%

Lösungsmittel

methylene chloride

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeTo a -20° C.
2. 2
   workup.STIRRINGstirred for an additional 30 minutes
3. 3
   SonstigeThe organic layer was separated
4. 4
   Waschenwashed with water (3×100 mL)
5. 5
   Trocknendried over magnesium sulfate
6. 6
   Einengenconcentrated in vacuo

Vorschrift

To a -20° C. solution of cycloheptylamine (6.37 mL, 50.0 mmol) and diisopropylethylamine (9.58 mL, 55.0 mmol) in methylene chloride (250 mL) was slowly added bromoacetyl bromide (4.78 mL, 55.0 mmol). The reaction mixture was warmed to room temperature over 20 minutes and stirred for an addition 30 minutes. The reaction mixture was diluted with water (100 mL) and stirred for an additional 30 minutes. The organic layer was separated, washed with water (3×100 mL), dried over magnesium sulfate and concentrated in vacuo to afford a beige solid (10.5 g). The crude material was further purified by silica gel flash column chromatography using hexane-ethyl acetate (1:1) as the eluent to give the purified title compound as a whim solid (9.77 g, 83%).

Quelle