Reaktion #305343

ord-a01969a549c042219f0cc70650620c13

Reaktionsgleichung

NCCC(c1ccccc1)c1ccc2c(cnn2-c2ccc(F)cc2)c1.O=C(O)C(F)(F)F
3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-phenylpropan-1-amine TFA salt
O=S(=O)(Cl)CC(F)(F)F
2,2,2-trifluoroethanesulfonyl chloride
→
O=C(NCCC(c1ccccc1)c1ccc2c(cnn2-c2ccc(F)cc2)c1)C(F)(F)F
2,2,2-trifluoro-N-(3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-phenylpropyl)acetamide
Ausbeute 99.7%

Edukte

NCCC(c1ccccc1)c1ccc2c(cnn2-c2ccc(F)cc2)c1.O=C(O)C(F)(F)F
3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-phenylpropan-1-amine TFA salt
O=S(=O)(Cl)CC(F)(F)F
2,2,2-trifluoroethanesulfonyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared from 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-phenylpropan-1-amine TFA salt (25 mg, 0.05 mmol) by adding 2,2,2-trifluoroethanesulfonyl chloride under the General Coupling Method B conditions. Obtained 22 mg (82%) of 2,2,2-trifluoro-N-(3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-phenylpropyl)acetamide. MS found: (M+H)+=442.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08198311B2uspto-grants-2012_06