Reaktion #305102

Reaktionsgleichung

compound 70

4-{[(2R)-2,3-dihydroxypropyloxy]phenyl}butylamine

compound 72

N-Cbz-4-{[(2S)-2,3-dihydroxypropyloxy]phenyl}butylamine

→

Amine

Ausbeute 99.0%

4-{[(2S)-2,3-dihydroxypropyloxy]phenyl}butylamine

Ausbeute 99.0%

Reaktionsbedingungen

Vorschrift

Compound 73 was prepared in a similar fashion to the synthesis of compound 70 starting from compound 72 (1.67 g, 4.5 mmol). Amine 73 (1.06 g, 99%) was isolated as a white solid. 1H NMR (300 MHz, DMSO-d6) δ 1.32 (m, 2H), 1.54 (m, 2H), 2.55 (m, 2H), 3.45 (m, 2H), 3.75 (m, 3H), 3.94 (m, 2H), 6.83 (d, 2H), 7.08 (d, 2H).

Quelle