Reaktion #304609

Reaktionsgleichung

EtOAc

K2CO3

2-hydroxy-4-(methoxymethoxy)benzaldehyde

3-methyl 2-butanal

→

7-(methoxymethoxy)-2,2-dimethyl-2H-chromene-3-carbaldehyde

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe insoluble materials were removed by filtration through celite
2. 2
   Einengenthe filtrate was concentrated under reduced pressure
3. 3
   SonstigeThe residue was purified by silica gel column chromatography (automatic purification device, hexane:EtOAc=95:5 to 70:30)

Vorschrift

K2CO3 (835 mg) was suspended in dioxane (40 mL), and 2-hydroxy-4-(methoxymethoxy)benzaldehyde (1 g) and 3-methyl 2-butanal (0.787 mL) were added thereto, followed by stirring at 110° C. overnight. EtOAc was added thereto, the insoluble materials were removed by filtration through celite, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (automatic purification device, hexane:EtOAc=95:5 to 70:30) to obtain 7-(methoxymethoxy)-2,2-dimethyl-2H-chromene-3-carbaldehyde (320 mg) as a yellow oil.

Quelle