Reaktion #304361

Reaktionsgleichung

t-BuOK

4-(2-methanesulfonyloxyethyl)piperidine-1-carboxylic acid tert-butyl ester

furo[3,2-c]pyridin-2-ylmethanol

→

title compound

4-[2-(Furo[3,2-c]pyridin-2-ylmethoxy)ethyl]piperidine-1-carboxylic acid tert-butyl ester

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction was heated
2. 2
   Temperaturunder reflux for 6 h
3. 3
   Sonstigequenched with saturated aqueous NH4Cl
4. 4
   ExtraktionThe mixture was extracted twice with EtOAc
5. 5
   Waschenthe combined organic extracts were washed with brine
6. 6
   Trocknendried (MgSO4)
7. 7
   Filtrationfiltered
8. 8
   Einengenconcentrated
9. 9
   SonstigeThe residue was purified by column chromatography (EtOAc-MeOH, 1:0 to 50:1)

Vorschrift

t-BuOK (45 mg, 401 μmol) and 4-(2-methanesulfonyloxyethyl)piperidine-1-carboxylic acid tert-butyl ester (134 mg, 436 μmol) were added to a stirred solution of furo[3,2-c]pyridin-2-ylmethanol (Preparation 4, 50 mg, 336 μmol) in anhydrous THF (5 mL). The reaction was heated under reflux for 6 h, before being cooled to 20° C. and quenched with saturated aqueous NH4Cl. The mixture was extracted twice with EtOAc, then the combined organic extracts were washed with brine, dried (MgSO4), filtered, and concentrated. The residue was purified by column chromatography (EtOAc-MeOH, 1:0 to 50:1) to furnish the title compound: RT=2.86 min; m/z (ES+)=361.3 [M+H]+.

Quelle