Reaktion #304084

Reaktionsgleichung

(S)-tert-Butyl 1-amino-3-(4-iodophenyl)-1-oxopropan-2-ylcarbamate

trifluoroacetic acid

→

(S)-2-Amino-3-(4-iodophenyl)propanamide

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated to ˜12 mL in vacuo
2. 2
   workup.STIRRINGThe residue was stirred for 2 days
3. 3
   workup.DISSOLUTIONdissolved in ethyl acetate/dichloromethane
4. 4
   Waschenwashed with water containing an excess of sodium bicarbonate
5. 5
   SonstigeThe organic layer was dried
6. 6
   Sonstigeevaporated to the sub-titled compound (1.52 g)

Vorschrift

(S)-tert-Butyl 1-amino-3-(4-iodophenyl)-1-oxopropan-2-ylcarbamate (Example 1, step (i), 2.41 g) was stirred in dichloromethane (125 mL) and to the suspension was added trifluoroacetic acid (8 mL). The mixture was stirred for 2 h and then concentrated to ˜12 mL in vacuo. The residue was stirred for 2 days, dissolved in ethyl acetate/dichloromethane and washed with water containing an excess of sodium bicarbonate. The organic layer was dried and evaporated to the sub-titled compound (1.52 g).

Quelle