Reaktion #304014

Reaktionsgleichung

1-butanol

(8-chloro-2-(2-chlorophenyl)quinolin-3-yl)-methanamine

tert-butyl 7-chloro-3H-imidazo[4,5-b]pyridine-3-carboxylate

diisopropylethylamine

→

N-((8-chloro-2-(2-chlorophenyl)-quinolin-3-yl)methyl)-3H-imidazo[4,5-b]pyridin-7-amine

Ausbeute 15.0%

Lösungsmittel

A-1216

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe mixture was concentrated
2. 2
   workup.ADDITIONthe residue was diluted with MeOH
3. 3
   SonstigeThe solution was purified by HPLC, 25%-45% of B in 35 min
4. 4
   workup.DISSOLUTIONThe collected fractions were dissolved in CH2Cl2
5. 5
   Waschenby washing with aq. NaHCO3
6. 6
   Trocknenthe CH2Cl2 layer was dried
7. 7
   Einengenconcentrated

Vorschrift

A sealed flask was charged with (8-chloro-2-(2-chlorophenyl)quinolin-3-yl)-methanamine, made in procedure E in A-1216 US PSP, tert-butyl 7-chloro-3H-imidazo[4,5-b]pyridine-3-carboxylate (109 mg, 429 μmol), diisopropylethylamine (0.075 mL, 429 μmol) and 1-butanol (2.0 mL, 21856 μmol). The mixture was subjected to microwave at 180° C. for 120 min. After cooled to room temperature, the mixture was concentrated, and the residue was diluted with MeOH. The solution was purified by HPLC, 25%-45% of B in 35 min. The collected fractions were dissolved in CH2Cl2 and neutralized by washing with aq. NaHCO3, the CH2Cl2 layer was dried, concentrated and gave N-((8-chloro-2-(2-chlorophenyl)-quinolin-3-yl)methyl)-3H-imidazo[4,5-b]pyridin-7-amine (20.2 mg, 15%), 1H NMR (DMSO-d6) δ ppm 12.72 (1H, s), 8.43 (1H, s), 8.15 (1H, s), 8.09 (1H, d, J=8.0 Hz), 8.05 (1H, d, J=8.0 Hz), 7.73-7.80 (2H, m), 7.63-7.70 (4H, m), 7.45 (1H, s), 6.13 (1H, d, J=8.0 Hz), 4.60 (2H, br). Mass Spectrum (ESI) m/e=420.0 (M+1).

Quelle