Reaktion #303926

ord-0a66329d8ae1407589377e763decb38a

Reaktionsgleichung

Cc1ccccc1-c1nc2c(C)cccc2cc1CCl
3-(chloromethyl)-8-methyl-2-o-tolyl-quinoline
[N-]=[N+]=[N-].[Na+]
NaN3
→
Cc1ccccc1-c1nc2c(C)cccc2cc1CN
(8-methyl-2-o-tolylquinolin-3-yl)methanamine

Edukte

Cc1ccccc1-c1nc2c(C)cccc2cc1CCl
3-(chloromethyl)-8-methyl-2-o-tolyl-quinoline
[N-]=[N+]=[N-].[Na+]
NaN3

Reagenzien

Keine

Lösungsmittel

CS(C)=O
DMSO

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared
  2. 2
    SonstigeAfter purification

Vorschrift

Prepared according to Procedure D using 3-(chloromethyl)-8-methyl-2-o-tolyl-quinoline (667 mg, 2.4 mmol) in DMSO (10 mL) was added NaN3 (500 mg, 3 eq). After purification, (8-methyl-2-o-tolylquinolin-3-yl)methanamine was obtained as pale yellow oil.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08193199B2uspto-grants-2012_06