Reaktion #303090

Reaktionsgleichung

Triethylamine

β-alanine methyl ester hydrochloride

2-chloropropionyl chloride

pyridine

→

oil

Ausbeute 93.2%

3-(2-chloropropionylamino)propionic acid methyl ester

Ausbeute 93.2%

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe reaction mixture was stirred for 2 hours
2. 2
   Waschenwashed sequentially with water, 1 N hydrochloric acid and saturated sodium bicarbonate
3. 3
   Trocknendried with magnesium sulfate
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated

Vorschrift

Triethylamine (1.63 g) was added to a suspension of β-alanine methyl ester hydrochloride (2.25 g) in dichloromethane (10 mL) and the reaction mixture was stirred for 30 minutes. After addition of pyridine (1.27 g) the reaction mixture was cooled to 0° C. A solution of 2-chloropropionyl chloride (2.04 g) in dichloromethane (10 mL) was added dropwise for 20 minutes. The reaction mixture was stirred for 2 hours, washed sequentially with water, 1 N hydrochloric acid and saturated sodium bicarbonate, dried with magnesium sulfate, filtered, and concentrated to give yellow oil (2.9 g, yield 93%).

Quelle