Reaktion #302940

Reaktionsgleichung

4-iodophenol

1-bromo-3-chloropropane

potassium carbonate

→

titled compound

Ausbeute 105.4%

1-(3-chloropropoxy)-4-iodobenzene

Ausbeute 105.4%

Lösungsmittel

2-butanone

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was cooled to room temperature
2. 2
   Extraktionextracted with ethyl acetate
3. 3
   WaschenThe organic layer was washed with water and brine
4. 4
   Trocknendried over sodium sulfate
5. 5
   Einengenconcentrated under reduced pressure

Vorschrift

To a solution of 4-iodophenol (20.0 g) and 1-bromo-3-chloropropane (18.6 g) in 2-butanone (200 mL), potassium carbonate (25.1 g) was added and stirred at 100° C. for 5 hours. The reaction mixture was cooled to room temperature, diluted with water and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over sodium sulfate and concentrated under reduced pressure to give the titled compound (28.4 g) as an orange-colored oil.

Quelle